http://www.med-ed.virginia.edu
Toxic Granulation :
- excessive granulation
- response to enhanced lysosome enzyme production
- vivid blue-black coloration
- clusters of toxic granules appear in neutrophils
http://www.nejm.org/doi/full/10.1056/NEJMicm040332
Toxic Vacuolization :
- changes in segmented neutrophils
- vacuoles appear in the cytoplasm of this cell and may be small or large
- occurs from :
- prolonged exposure of blood to drugs such as sulfonamides
- tubes held for a long period of time
- delayed creation of smear – pseudo-vacuolization
http://www.med-ed.virginia.edu
Döhle Bodies :
- cytoplasmic inclusion composed of ribosomal RNA
- near the cytoplasmic membrane
- rod-shaped pale bluish-gray structure
- may be seen in nonpathological conditions such as pregnancy
http://www.nature.com/modpathol/journal/v17/n5/fig_tab/3800075f3.html
Human Ehrlichiosis (HE) :
- group of tick-borne diseases that show a notable white cell inclusion
- human monocytic ehrichiosis
- caused by rickettsia-like bacteria Ehrlichia Chafeensis
- human granulocytic ehrlichiosis
- caused by the rickettsia-like bacteria Ehrlichia phagocytophilia
- onset of high fever, chills and headache
- low white counts
- elevated liver enzyme
- mulberry-like inclusions may be seen in bone marrow granulocytes or monocytes
Hypersegmentation :
- normal neutrophils have 3-5 lobes in the nucleus
- hypersegmented contains >5 lobes
- usually seen in megaloblastic processes
- folic acid
- pernicious anemia
- vitamin B12 deficiency
reticulousness 